5. Morbius

Created by Roy Thomas and Gil Kane, Dr. Michael Morbius was a scientist with a disfiguring blood disease. As have so many other mad geniuses, he attempted to cure himself with science. He ended up a blood-sucking vampire with super-strength, the power of flight, and healing abilities.

4. The Lizard

The Lizard is one of Spidey’s most well-known opponents. First appearing in 1963, he’s exactly what his name suggests – a lizard-man with lethal abilities and psychotic motivations.

3.Mysterio

Mysterio is actually an actor named Quentin Beck. His knowledge of special movie effects gave him all he needed to start a life of crime, starting by trying to frame Spider-Man for a bank robbery. Over the years, he’s been defeated numerous times by various villains, but he keeps coming back for more.

2. Green Goblin

In later issues, others would take up the role of the Goblin, including Norman’s son and Peter Parker’s best friend Harry Osborn.

1. Doctor Octopus

Doc Ock has had some strange story arcs throughout the series, dying and being resurrected on more than one occasion. He even switches bodies with Peter Parker at one point, becoming the Superior Spider-Man.